Posts Tagged ‘sex drive’

Testosterone For Females: Is There A Role?

October 31, 2015

Andrew Siegel MD   10/31/15

Many of my recent entries have been male-oriented. It’s time to give the fairer sex some equal time.

BodybuildingWoman

(Above image entitled: Mujer culturista mostrando la musculación de la espalda y los brazos, author: roonb, created November 2007, no changes to original image, creative commons license 2.0, link to license: creativecommons.org/licenses/by/2.0)

Female sexual dysfunction (FSD) is a common condition that may encompass diminished desire, decreased sexual arousal, difficulty achieving orgasm and pain with sexual intercourse. The most prevalent issue is decreased or lack of sexual desire, now given the formal medical title: Hypoactive Sexual Desire Disorder (HSDD), although I prefer the less formal, non-medical version: “Honey, I’m not in the mood.”

Testosterone (T)—the key male sexual hormone—has a strong role in stimulating sexual drive in both men and women and has long been used to manage diminished female libido and other sexual issues, despite it not being approved by the FDA for this intent. It has been shown to improve libido, arousal, sexual pleasure and overall sexual satisfaction.

Testosterone In Women

Although T is the major male sex hormone, it is also vital in females, similarly to how estrogen is the key female sex hormone, but has important functions in males as well.  In pre-menopausal women, the ovaries and adrenals (those paired glands that sit atop each kidney) each produce about 25% of T, with the other 50% produced by muscle and fat cells. The two biggest factors leading to a decrease in blood T levels are aging and menopause.

Pre-menopausal women produce about 0.25 mg T/day. (Men produce 6-8 mg T/day, about 25 times as much as females). Even after menopause, the ovaries continue to produce T.  Women who have their ovaries removed experience a dramatic decrease in T.

One of the major limitations of measuring T levels in females is the lack of reliable and accurate assays to precisely measure T levels at such low concentrations. Another shortcoming is that there is no concensus on what precisely is the lower level of T in females.

Symptoms of low T in females may include diminished libido, fatigue, lack of energy, decrease in well being, impaired concentration, depression and difficulties with arousal and orgasm. These symptoms of low T are very non-specific and have quite an overlap with the symptoms and changes that accompany normal aging, insufficient or poor quality sleep, overworking and/or an unhealthy lifestyle. Signs of low T in females are decreased muscle mass, increased body fat, thinning hair and bone wasting (osteopenia).

Decreased Female Libido

This is defined as absent or reduced interest in and arousal from sex, erotic thoughts, fantasies, or written, verbal, and visual cues.  There is usually a reduction in initiation of sex and reception to partner’s initiation attempts. When sexual activity does occur, there is often absent or reduced sensation (both genital and non-genital), excitement and pleasure. Although low T is an important cause of decreased sex drive, there are many other competing causes including other sexual issues such as pain with intercourse or inability to orgasm, medical diseases, medications, unhealthy lifestyle, fatigue, pregnancy, breast-feeding, menopause, boredom, stress, many other psycho-emotional factors and relationship issues.

Treatment Options

T has been shown to improve sexual function in both pre-and post-menopausal women. Testosterone replacement therapy (TRT) should only be a consideration after other causes of diminished libido have been eliminated.  It is challenging to predict which women will respond best to T therapy. Another concern is the safety and potential side effects with the long-term use of TRT.

There are currently no FDA-approved TRT products for women in the USA, so any usage is off-label. Products designed for TRT in males are available in a variety of preparations, including skin patches, gels and creams, buccal (gum) preparation, nasal gels, injections and long-acting pellets implanted in fatty tissue. Common side effects of TRT include unwanted hair growth, acne and mood or personality changes.

Addyi (Flibanserin) is a new oral medication for diminished libido.  It is currently being marketed largely to females, but is purportedly effective for both genders. It is the first FDA- approved prescription for diminished sex drive and has been referred to as “pink Viagra.” It is not TRT, but works centrally by affecting serotonin levels. It just became available this month.

Excellent reference on this subject: Khera, M. Testosterone Therapy for Female Sexual Dysfunction. Sex Med Rev 2015;3:137-144

Wishing you the best of health,

2014-04-23 20:16:29

http://www.AndrewSiegelMD.com

A new blog is posted every week. To receive the blogs in the in box of your email go to the following link and click on “email subscription”: www.HealthDoc13.WordPress.com

Author of Male Pelvic Fitness: Optimizing Sexual and Urinary Health: available in e-book (Amazon Kindle, Apple iBooks, Barnes & Noble Nook, Kobo) and paperback: www.MalePelvicFitness.com. In the works is The Kegel Fix: Recharging Female Pelvic, Sexual and Urinary Health.

Co-creator of Private Gym, a comprehensive, interactive, FDA-registered follow-along male pelvic floor muscle training program. Built upon the foundational work of Dr. Arnold Kegel, Private Gym empowers men to increase pelvic floor muscle strength, tone, power, and endurance: www.PrivateGym.com or Amazon.

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Enhancing Male Sexual Function: An Update

January 24, 2014

Blog #138  Andrew Siegel MD

“But the wheel of time turns, inexorably. True rigidity becomes a distant memory; the refractory period of sexual indifference after climax increases; the days of coming are going. Sexually speaking, men drop out by the wayside. By 65, half of all men are, to use a sporting metaphor, out of the game; as are virtually all ten years later, without resort to chemical kick-starting.”

—Tom Hickman
God’s Doodle: The Life and Times of the Penis

The term ED (Erectile Dysfunction) is commonly bandied about these days. There are plenty of men who do not have a dysfunction, but simply do not have quite the function they had when they were younger. Their “plumbing” is intact and they function without complaint from their partner, but things are just, well… different from the way they were.

Simply stated, change is to be expected coincident with the aging process. Performance ability with respect to virtually any physical activity will decline with aging and this explains why most professional athletes are in their twenties or early thirties. Everything eventually goes to ground, but hopefully does so slowly.

Young men can achieve a rock-hard erection simply by seeing an attractive woman or thinking some vague sexual thought. As we get older, it is not uncommon for erotic thoughts or sights to be insufficient to provoke an erection, with the need for direct “hydraulic” assistance through touch. Some of the common male sexual changes that occur with aging are the following: diminished sex drive; decreased rigidity and durability of erections; decrease in volume, force, and trajectory of ejaculation; decreased orgasm intensity; and an increase in the time it will take for recovery before being able to get another erection (refractory period).

Altered sexual function can present in various forms, dimensions and magnitudes.  Some men can achieve a very rigid erection readily capable of penetration, but then, much to the bewilderment and dismay of its owner, display a short “attention” span and deflate before business is fully conducted—one might refer to this as penile attention deficit disorder (PADD).  (See Urban Dictionary for full definition—guess who coined this term!)

http://www.urbandictionary.com/define.php?term=penile+attention+deficit+disorder+%28padd%29

Other men are capable of obtaining, at best, a partially inflated erection that cannot penetrate, despite pushing, shoving and manipulating. For some, an erection is but a pleasant memory lodged deep in the recesses of the mind.  So what can a man do?

For starters, good lifestyle habits are first-line measures. Proper eating habits, exercise, adequate quality and quantity of sleep, tobacco avoidance, use of alcohol in moderation, stress avoidance, and a balanced lifestyle are simple means of optimizing sexual potential.  The “golden rule” is relevant to one’s penis: Be nice to your penis (in terms of a healthy lifestyle) and it will be nice to you; treat your penis poorly and it will rebel…and no one wants a rebellious penis!

Pelvic floor muscle exercises are a first-line measure for helping to manage erectile dysfunction. When the pelvic floor muscles contract, they increase blood flow to the genitals, specifically by the actions of the two musclesthe bulbocavernosus and ischiocavernosus—that become engaged at the time of an erection. Contractions of these muscles help prevent the exit of blood from the penis, enhancing rigidity. With each contraction of these muscles, a surge of blood flows into the penis. Additionally, they act as powerful struts to support the roots of the penis, the foundational support that, when robust, will allow a more “skyward” angling erection. It stands to reason that if you can increase the strength, tone and conditioning of these muscles through pelvic muscle floor training, they will function in an enhanced manner—namely more powerful contractions, and more penile rigidity and stamina.

What to do when one employs lifestyle measures and pelvic exercises, but the rebel-down-below still displays some degree of penile attention deficit disorder?  One should stick to the lifestyle measures and the exercises, but consider adding a pill to the regimen.

The Rolling Stones’ song, “Mother’s Little Helper,” referred to Valium in terms of a little yellow pill. In 1998, a little blue pill was manufactured that could be considered “Daddy’s Little Helper”—aka Viagra.  This medication was discovered by chance. In an effort to treat high blood pressure and chest pain, Pfizer scientists conducted a clinical trial with this experimental medication that caused blood vessels to dilate (open).  It did not work particularly well for the intended purposes, but had a side effect in that it dramatically improved erections.  When the study ended, the participants were profoundly disturbed that the drug was no longer available. The rest is simply history

The PDE5 Inhibitor class of medications includes the following: Viagra, Levitra, Cialis, and Stendra.  Stendra is now FDA approved and available as of last week.

Viagra (Sildenefil). Viagra was born as a fusion of the words “vigor” (physical strength) and “Niagara” (the most powerful waterfall in North America). Viagra is available in three doses: 25 mg, 50 mg, and 100 mg.  It is taken on demand and once swallowed, it will produce an erection in most men within 30-60 minutes if they are sexually stimulated, and will remain active for up to 8 hours.

Levitra (Vardenefil).  This is an oral medication similar to Viagra, available in 5 mg, 10 mg, and 20 mg doses.

Cialis (Tadalafil).  This is an oral medication similar to Viagra, available in 2.5 mg, 5 mg, 10 mg, and 20 mg doses. The fact that it lasts for 36 hours or so has earned it the nickname “the weekender,” as it can be taken on Friday evening and remains effective for the remainder of the weekend without the need for an additional dose.  This affords a considerable advantage in terms of spontaneity.  In 2012, daily lower doses of Cialis were FDA approved for the management of urinary symptoms due to benign prostate enlargement.

Who Knew?  Cialis—a pill that helps erections and urination…now that’s a winning combo for the aging male.  Talk about killing two birds with one stone!

Stendra (Avanafril).  This supposedly has the advantage of a very rapid onset of action.  It is available in 50 mg, 100 mg, and 200 mg doses.

These medications are not for everybody and are not effective in everyone. However, for many, they are highly beneficial in treating ED and in improving erectile function that may have diminished a bit over the years.  Many men use a low dosage (typically one-quarter of the full dosage) of these medications “recreationally,” meaning that they can function perfectly well without the medication, but with it their function is enhanced significantly.

BOTTOM LINE: If you are experiencing ED or just some changes in function, there are several courses of action to improve the condition: first-line treatments include a healthy lifestyle as well as pelvic floor muscles exercises to increase erectile strength, endurance, stamina and rigidity. Should these measures fail to restore erections to the degree desired, there are oral medications that can prove beneficial.  And if pills don’t help enough, us urologists have many other tricks up our sleeves, but that is a topic for another day.

TAKE HOME MESSAGE:  Even if you are young and functioning superbly, pursue a healthy lifestyle and do pelvic floor exercises to maintain that functional status!

Andrew Siegel, M.D.

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Author of: Male Pelvic Fitness: Optimizing Sexual and Urinary Health; in press and available in e-book and paperback formats in March 2014. www.MalePelvicFitness.com

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