Posts Tagged ‘Andrew Siegel MD’

Noctiva: A New Treatment for Annoying Nighttime Peeing

June 23, 2018

Andrew Siegel MD    6/23/18

bottles-8MM[1]There is compelling medical evidence that a good night’s sleep is of vital importance for one’s health. We recognize this intuitively when we compare how we feel after a night of sleeping well as opposed to a night of sleep deprivation, but it goes way beyond mere fatigue.  Sleeping well is a key component to cognitive and physical fitness as well as overall health, equally important to diet and exercise. Aside from daytime fatigue, weight gain because of altered eating patterns, and increased risk of traffic accidents and fall-related nighttime injuries, sleep deprivation has been associated with an assortment of medical problems that negatively affect quality and quantity of life.  

Although there are many reasons for failing to obtain sufficient sleep, one such cause is interrupted sleep from the need to frequently empty one’s bladder. This can be disruptive to achieving a good night’s sleep, with many nighttime voiders unable to get back to sleep after urinating. Today’s entry reviews a new medication that can help sleep-disruptive nighttime urinating when it is caused by overproduction of urine, a causal factor in over 80% of cases of nighttime urination.

Nighttime urination—nocturia in medical speak—is a complex condition that aside from affecting quality of sleep and quality of life can be a symptom of underlying medical issues, e.g., diabetes, obstructive sleep apnea and cardiovascular issues. It is common in both women and men, tends to increase with aging, and its underlying basis is often multifactorial.  If it occurs once or twice a night and is not too bothersome and one can readily get back to sleep, it is no big deal.  However, if it occurs more than twice a night and is sleep-disruptive, it may be time to consider a means of improving the situation. Importantly, although nocturia is typically a complaint that drives patients to urologists, most of the time the nocturia is NOT urological in origin.

A simple test to help assess nocturia is a 24-hour voiding diary, which requires a pen and paper, a watch or clock and a measuring cup. The time at which urination occurs and the volume of each urination are recorded. Typical bladder capacity is 10–12 ounces with 4–6 urinations per 24 hours. Such a diary will help differentiate between those with a reduced bladder capacity, those who produce lots of urine only while sleeping, and those who produce lots of urine both day and night.

Reduced bladder capacity is often a sign of urological issues including overactive bladder, benign prostate enlargement, neurological diseases affecting the bladder, and loss of elasticity of the bladder as may occur with pelvic radiation.

Those who produce lots of urine only while sleeping are commonly found to have the following causes: increased fluid intake in the evening, obstructive sleep apnea, edematous states such as congestive heart failure, and failure to produce sufficient quantity of a hormone that regulates urine production.

Drinking a few cups of coffee or tea after dinner or a few beers before bedtime will cause nighttime urination and has an obvious solution. Obstructive sleep apnea is a under-appreciated and common cause of full-volume nighttime urination that when treated with CPAP (continuous positive airway pressure) or other means will significantly reduce the nocturia. Edema is fluid within the tissues–-typically the ankles and legs–that tends to accumulate aided by gravity over the course of the day. Upon assuming the lying-down position when sleeping, the legs are relatively elevated as opposed to standing and this tissue fluid returns into circulation, causing the kidneys to increase urine production. In general, those with peripheral edema go to sleep with ankles and legs engorged with edema fluid and wake up with thinner legs, as the return of some of the fluid to the circulation and the subsequent increased urination rids them of this. Another possibility is an abnormality in the nocturnal secretion of anti-diuretic hormoneThis pituitary hormone causes the kidneys to concentrate urine and pull water back into the circulation; nocturia may occur because of an age associated decline in its secretion while sleeping.

Those who produce lots of urine both day and night often have overzealous fluid intake, diabetes mellitus or diabetes insipidus, or are on certain medications (e.g., lithium) that can cause the problem.

Noctiva (Desmopressin) to treat nocturnal excessive urine production

One of the most common reasons for nocturia is excessive nighttime urine production, defined as nighttime urine volume exceeding 1/3 of the 24-hour urine production.  If this is demonstrated on the voiding diary, you may be a candidate for this anti-diuretic medication that works by decreasing nocturnal urinary production.

Desmopressin is a synthetic version of anti-diuretic hormone. The function of this hormone is to put the “brakes” on the kidneys so that the kidneys do not allow excessive loss of body water, which could be detrimental to one’s health and lead to severe dehydration. For years, desmopressin has been used for children who are bed wetters.

Noctiva (Desmopressin) nasal spray is a new formulation of intranasal desmopressin for those who have full-bladder volume nocturia two or more times.  It is a modification of desmopressin that is designed to enhance absorption from the nasal lining, available in doses of 0.83 and 1.66 microgram.  One spray in either nostril is used about 30 minutes prior to sleep.

The absorption of this product is enhanced as compared to that of the oral version (8% vs. 0.3%), which means more consistent dosing and rapid absorption and elimination allowing more rapid onset and less prolonged drug activity.  It is well tolerated with the most common side effect low levels of sodium and other side effects including nasal irritation, nasal congestion, nosebleeds, sneezing, and high blood pressure.  The drug cannot be used in the face of excessive fluid intake, low serum sodium, steroids or loop diuretic use, heart failure, uncontrolled high blood pressure, poor kidney function, and with illnesses causing fluid and electrolyte imbalances. Sodium levels need to be monitored periodically.

Bottom Line: Nocturnal urinary frequency should be investigated to determine its cause, which may in fact be related to conditions other than urinary tract issues.  Nighttime urination is not only bothersome but may also pose real health risks as chronically disturbed sleep can lead to a host of collateral wellness issues. Noctiva is a new addition to the armamentarium to combat nighttime urination when it is due to excessive nocturnal urinary production.

Wishing you the best of health,

2014-04-23 20:16:29

A new blog is posted weekly. To receive a free subscription with delivery to your email inbox visit the following link and click on “email subscription”:  www.HealthDoc13.WordPress.com

Dr. Andrew Siegel is a physician and urological surgeon who is board-certified in urology as well as in female pelvic medicine and reconstructive surgery.  He is an Assistant Clinical Professor of Surgery at the Rutgers-New Jersey Medical School and is a Castle Connolly Top Doctor New York Metro Area, Inside Jersey Top Doctor and Inside Jersey Top Doctor for Women’s Health. His mission is to “bridge the gap” between the public and the medical community.

Dr. Siegel has authored the following books that are available on Amazon, iBooks, Nook and Kobo:

MALE PELVIC FITNESS: Optimizing Sexual & Urinary Health

THE KEGEL FIX: Recharging Female Pelvic, Sexual and Urinary Health 

PROMISCUOUS EATING: Understanding and Ending Our Self-Destructive Relationship with Food

Cover

These books are written for educated and discerning men and women who care about health, well-being, fitness and nutrition and enjoy feeling confident and strong.

Dr. Siegel is co-creator of the male pelvic floor exercise instructional DVD (female version is in the works): PelvicRx

New video on female pelvic floor exercises:  Learn about your pelvic floor

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Try This First Before Seeing A Urologist

June 9, 2018

Andrew Siegel MD  6/9/2018

Picture1

Many suffer with urinary urgency and frequency, requiring repeated trips to the bathroom.  Although not serious or life-threatening, it is annoying and inconvenient.  After happening repeatedly, it can be become an ingrained habit that is difficult to break.  Concerns surface about sitting in traffic, traveling, seeing a Broadway show, getting the right seat on an airplane, etc.

 If you are dealing with an urgency/frequency issue, you may benefit from “bladder retraining.”  It is relatively simple, requires neither medication nor surgery, and can help you control when you urinate, how often you urinate and allow you to delay urinating. 

What happens under normal circumstances

As the bladder gradually fills, most people ignore the initial sense of urgency, continuing to go about their life and carrying on with their activities.  As the bladder continues to fill, they continue to tune out the sense of urgency until the point that it becomes compelling enough so that they are motivated to leave their activity and go to the bathroom to empty their bladder.

What happens to the frequent urinator

For one reason or another, the frequent urinator often becomes “hyper-vigilant” about their sense of urinary urgency.  For him or her, the bladder is “front burner” and not “back burner.”  This may be based on a previous physical bladder problem that gave rise to the hyper-focus, commonly a urinary infection. The frequent urinator often responds to the initial sense of urgency by acting upon it and heading to the bathroom to empty their bladder.  When this behavior is habitually repeated, it becomes a dysfunctional ingrained habit—the “new normal,” and again, a habit that is tough to break. The bottom line is that when there is excessive focus on the sensations arising from the bladder (or for that matter, any part of the body), one will be hyper-acutely aware of sensations that they normally are not cognizant of.

As another example of this, if you focus on the weight of your watch on your wrist or your ring on your finger, within a matter of minutes, their presence will start annoying you.  No good comes of when background becomes foreground!

A 24-hour bladder diary (log of urination recording time of urinating and the volume of each urination) is a simple but helpful tool in sorting out the different causes of urgency/frequency.  Since normal bladder capacity is about 12 ounces, if the diary shows frequent voids of full volumes, the problem is most likely related to excessive fluid intake (or rarely a kidney or hormonal problem that can cause excessive urinary production).  However, if the diary shows frequent voids of small volumes (e.g., 4 ounces), the problem can often be improved with bladder retraining. If the diary shows frequent voids of small volumes during the day, but full volume voids while sleeping or no voids while sleeping, it points to frequency on a psychological basis and also can often be improved with bladder retraining. It is important to know that frequent voiding of smaller volumes is not always a dysfunctional habit and may be on the basis of prostate or bladder issues that might require the services of your friendly urologist.  However, no harm can come from an initial attempt at bladder retraining.

Fixing it

The goal of bladder retraining is to break the dysfunctional habit and restore normal—or at least better—bladder functioning.  Bladder retraining can be challenging, yet rewarding, and requires a positive attitude and being willing, informed and engaged.

  1. FLUID AND CAFFEINE IN MODERATION

Urgency will often not occur until a “critical” urinary volume is reached, and by limiting fluid intake, it will take a longer time to achieve this volume. Try to sensibly restrict your fluid intake (without causing dehydration) in order to decrease the volume of urinary output. Caffeine (present in tea, coffee, colas, some energy drinks and chocolate) can increase urinary output and is a urinary irritant, so it is best to limit intake of these beverages/foods.  Additionally, many foods—particularly fruits and vegetables—have hidden water content, so moderation applies here as well.  It is important to try to consume most of your fluid intake before 7:00 PM to improve nighttime frequency.

  1. ASSESS MEDICATIONS

Diuretic medications (water pills) can contribute to frequency by design. If you are on a diuretic, it may be worthwhile to check with your medical doctor to see if it is possible to change to an alternative, non-diuretic medication. This will not always be feasible, but if it is, may substantially improve your frequency.

  1. AVOID BLADDER IRRITANTS

Irritants of the urinary bladder may be responsible for worsening your symptoms.  Consider eliminating or reducing one or more of the following irritants and then assessing whether your frequency improves:

Tobacco

Alcoholic beverages

Caffeinated beverages: coffee, tea, colas and other sodas and certain sport and energy drinks

Chocolate

Carbonated beverages

Tomatoes and tomato products

Citrus and citrus products: lemons, limes, oranges, grapefruits

Spicy foods

Sugar and artificial sweeteners

Vinegar

Acidic fruits: cantaloupe, cranberries, grapes, guava, peaches, pineapple, plums, strawberries

Dairy products

  1. URGENCY INHIBITION

The act of reacting to the first sense of urgency by running to the bathroom needs to be modified.  Stop in your tracks, sit, relax and breathe deeply. Pulse your pelvic floor muscles rhythmically to deploy your own natural reflex to resist and suppress urinary urgency (more about this below).

  1. INTERVAL TRAINING

Imposing a gradually increasing interval between urinations will help establish a more normal pattern of urination. If you are urinating small volumes on a frequent basis, your own sense of urgency is not providing you with accurate information about the status of your bladder fullness.  Urinating by the “clock” and not by your own sense of urgency will keep your voided volumes more appropriate. Voiding on a two-hour basis is usually effective as a starting point, although the specific timetable has to be tailored, based upon the bladder diary.  A gradual and progressive increase in the interval between voiding can be achieved by consciously delaying urinating.  A goal of an increase in the voiding interval by 15-30 minutes per week is desirable.  Eventually, a return to more acceptable voiding intervals is possible. The urgency inhibiting techniques mentioned above are helpful with this process.

  1. BOWEL REGULARITY

A rectum full of gas or fecal material can contribute to urinary difficulties. Because of the proximity of the rectum and bladder, a full rectum can put internal pressure on the bladder, resulting in worsening of urgency and frequency.

  1. PELVIC FLOOR MUSCLE TRAINING (PFMT)

The pelvic floor muscles (PFM) play a VITAL role in inhibiting urgency and frequency.  Voluntary rhythmic pulsing of the PFM can inhibit urgency and frequency and PFMT hones the inhibitory reflexes between the pelvic floor muscles and the bladder.

Initially, one must develop an awareness of the presence, location, and nature of the PFM and then train these muscles to increase their strength and tone.  These are not the muscles of the abdominal wall, thighs or buttocks.  A simple means of recognizing the PFM for a female is to insert a finger inside her vagina and squeeze the PFM until the vagina tightens around her finger.  Another means of identifying the PFM for either gender is to start urinating and when about half completed, to abruptly stop the stream. It is the PFM that allows one to do so.  When feeling the urge to urinate, rhythmic pulsing of the PFM–“snapping” the PFM several times—can diminish the urgency and delay a trip to the bathroom.

  1. LIFESTYLE MEASURES: HEALTHY WEIGHT, EXERCISE, TOBACCO CESSATION

The burden of excess pounds can worsen frequency by putting pressure on the urinary bladder, similar to the effect that excessive weight has on your knees. Even a modest weight loss may improve the situation.  Pursuing physical activities can help maintain general fitness and improve frequency. Lower impact exercises–yoga, Pilates, cycling, swimming, etc.–can best help alleviate pressure on the urinary bladder by boosting core muscle strength and tone and improving posture and alignment. The chemical constituents of tobacco constrict blood vessels, impair blood flow, decrease tissue oxygenation and promote inflammation, compromising the bladder, urethra and pelvic muscles.  By eliminating tobacco, symptoms can be improved.

Bottom Line: Bladder retraining can be an effective means of whipping your bladder (and your mind) into shape to help convert dysfunctional habits into more normal and appropriate voiding patterns.  This has the potential of helping many people. However, if the aforementioned strategies fail to improve your situation, you should have a basic urological evaluation, including a urinalysis (dipstick exam of the urine), a urine culture (test for urinary infection) if indicated, and determination of how much urine remains in your bladder immediately after emptying.  At times, tests such as cystoscopy (a visual inspection of the urethra and bladder with a narrow, flexible instrument) and urodynamics (sophisticated tests of bladder function) will need to be done as well. Urologists have the wherewithal to improve this situation and your quality of life.

Wishing you the best of health,

2014-04-23 20:16:29

A new blog is posted weekly. To receive a free subscription with delivery to your email inbox visit the following link and click on “email subscription”:  www.HealthDoc13.WordPress.com

Dr. Andrew Siegel is a physician and urological surgeon who is board-certified in urology as well as in female pelvic medicine and reconstructive surgery.  He is an Assistant Clinical Professor of Surgery at the Rutgers-New Jersey Medical School and is a Castle Connolly Top Doctor New York Metro Area, Inside Jersey Top Doctor and Inside Jersey Top Doctor for Women’s Health. His mission is to “bridge the gap” between the public and the medical community.

Dr. Siegel has authored the following books that are available on Amazon, iBooks, Nook and Kobo:

MALE PELVIC FITNESS: Optimizing Sexual & Urinary Health

THE KEGEL FIX: Recharging Female Pelvic, Sexual and Urinary Health 

PROMISCUOUS EATING: Understanding and Ending Our Self-Destructive Relationship with Food

These books are written for educated and discerning men and women who care about health, well-being, fitness and nutrition and enjoy feeling confident and strong.

Dr. Siegel is co-creator of the male pelvic floor exercise instructional DVD: PelvicRx

Female version in the works: Female PelvicRx

Little Tumors in the Kidney: Challenges and Solutions

June 2, 2018

Andrew Siegel MD    6/2/18

Years ago–prior to the advent of advanced means of imaging the abdomen–malignant growths of the kidney would manifest with symptoms.  The “classic triad” of symptoms and signs were pain, blood in the urine and a mass that could be felt on examination.  Nowadays, the vast majority of renal masses are asymptomatic, incidental (unexpected) findings picked up on imaging studies done for other issues. The widespread and liberal use of ultrasound, computerized tomography (CT) and magnetic resonance imaging (MRI) done for a variety of reasons not uncommonly result in the incidental finding of a small mass in the kidney, known as a small renal mass (SRM).  Urologists are the go-to doctors who manage renal masses, including SRMs, which can present challenges in term of how best to manage it.

small-kidney-tumor-right

SRM of right kidney on CT

 Evaluation

So, what to do when one is found to have a small mass in the kidney, often less than one inch (2.5 cm) in diameter?

A CT or MRI imaging study without and with contrast is recommended for the assessment of renal masses. The premise is that when a mass takes up contrast, it has a blood supply and is usually not a simple benign cyst containing fluid, but a solid mass that is considered malignant until proven otherwise.  Although these studies are capable of diagnosing and evaluating solid renal masses and distinguishing them from fluid-filled cysts, neither study is capable of distinguishing benign from malignant.

One possibility to address the shortcomings of CT and MRI is a CT-guided kidney biopsy.  It is an outpatient procedure performed by an interventional radiologist who obtains a tiny biopsy of the area of concern using CT guidance.  The biopsy is microscopically studied by a pathologist.  This can distinguish benign from malignant as well as provide tumor type and grade.  Such a biopsy can reduce unnecessary surgery for benign lesions and guide the selection of patients appropriate for monitoring and those who need to be treated.

Fact: About 20% of SRMs are potentially aggressive kidney cancers, 50% exhibit slow growth and are unlikely to ever be a problem, and 30% are benign.

Prognostic factors

Size is of significance, as larger masses have a higher risk of being malignant.  Mass size also predicts the possibility of spread, with a 2.4% risk in tumors under 3 cm versus 8.4% for tumors 3 – 4 cm. Another important factor is tumor growth rate, the average being 0.1 – 0.4 cm/year. Rapidly growing masses are at higher risk for progression and spread.

To treat or not

Active surveillance—careful interval imaging and follow-up with consideration for intervention if the situation merits a change—is a prudent means of management of the SRM in elderly patients, in those with significant medical problems who have a limited life expectancy, and those at high risk for surgery and surgical complications. Active surveillance is also an excellent option in patients who have a solitary kidney or significant kidney disease. Clinical studies have shown that management of SRMs with initial surveillance and delayed intervention does not compromise the success of the surgery or increase the risk of local spread or metastases.

On the other hand, a young, healthy patient with a long life expectancy merits definitive treatment. Typical treatment options are partial nephrectomy versus tumor ablation.  Partial nephrectomy is most often done via laparoscopy with robotic assistance and removes the mass with a margin of normal tissue, sparing the bulk of the kidney. An ultrasound probe is used to help the surgeon precisely image the tumor and its margins.

An alternative option is tumor ablation– the application of heat (radio-frequency) or cold (cryosurgery) directly into the SRM–in an effort to destroy the tumor while leaving the remaining kidney intact.  This can be performed percutaneously (using a needle placed through the skin without an incision) via CT imaging.

Wishing you the best of health,

2014-04-23 20:16:29

A new blog is posted weekly. To receive a free subscription with delivery to your email inbox visit the following link and click on “email subscription”:  www.HealthDoc13.WordPress.com

Dr. Andrew Siegel is a physician and urological surgeon who is board-certified in urology as well as in female pelvic medicine and reconstructive surgery.  He is an Assistant Clinical Professor of Surgery at the Rutgers-New Jersey Medical School and is a Castle Connolly Top Doctor New York Metro Area, Inside Jersey Top Doctor and Inside Jersey Top Doctor for Women’s Health. His mission is to “bridge the gap” between the public and the medical community.

Dr. Siegel has authored the following books that are available on Amazon, iBooks, Nook and Kobo:

MALE PELVIC FITNESS: Optimizing Sexual & Urinary Health

THE KEGEL FIX: Recharging Female Pelvic, Sexual and Urinary Health 

PROMISCUOUS EATING: Understanding and Ending Our Self-Destructive Relationship with Food

Cover

These books are written for educated and discerning men and women who care about health, well-being, fitness and nutrition and enjoy feeling confident and strong.

Dr. Siegel is co-creator of the male pelvic floor exercise instructional DVD (the female version is in the works): PelvicRx

 

Testosterone Treatment and Tiny Testicles: There is a Better Option

May 25, 2018

Andrew Siegel MD  5/25/18

“If a man is prescribed Food and Drug Administration approved testosterone for androgen deficiency, his overall health improves but his sperm production declines and his testes shrink. If he is prescribed off-label clomiphene citrate, his health improves and his sperm production is preserved, as does the size of his testicles.  This selective receptor estrogen modulator for male reproductive endocrine therapy must be a great new discovery, right? Wrong. It has been around for 50 years.”

Dr. Craig Niederberger, Department Head of Urology, University of Illinois School of Medicine

The Magic of Testosterone (T)

For the symptomatic man who has low levels of T, boosting levels of this male  “rocket fuel” hormone can result in a remarkable improvement of energy, sexuality (sex drive, erections, ejaculation), masculinity, mood, body composition (muscle and bone mass), mental focus and other parameters. However, men considering T treatment must understand that T is not a cure-all and must only be used under the circumstances of symptoms of low T and laboratory testing that shows low T.  Most certainly, T has been over-marketed, over-prescribed and certain side effects have been understated. It is vital to understand the side effects of T before committing to treatment.

T Science

Most T is made by the testicles. Its secretion is governed by the release of luteinizing hormone (LH) from the pituitary, the master gland in the brain. Some of T is converted to the female hormone estradiol (E). E is the primary hormone involved in the regulation of the pituitary gland. Under the circumstance of adequate levels of T, E feeds back to the pituitary to turn off LH production. This feedback loop is similar to the way a thermostat regulates the temperature of a room in order to maintain a relatively constant temperature, shutting the heat off when a certain temperature is achieved, and turning it on when the temperature drops.

The Effect of Long-Term T Replacement

So, what happens when you have been on long-term T? This externally sourced T, whether it is in the form of gels, patches, injections, pellets, etc., shuts off the pituitary LH by the feedback system described above so that the testes stop manufacturing natural T. Additionally, the testes production of sperm is stifled, problematic for men wishing to remain fertile. In other words, external T is a contraceptive! Nearly all men will have suppression of sperm production while on T replacement, less so with the gels vs. the injections or implantable pellets.

Thus, using T results in the testes shutting down production of sperm and natural T and after long-term T use, the testes can actually shrivel, becoming ghosts of their former functional selves. “Use it or lose it” is relevant to every organ in the body and external T essential puts the testes into hibernation and dormancy.

If you stop the T after long-term use, natural function does not resume anytime quickly. Although recovery usually occurs within 6 months or so, it may take several years and permanent detrimental effects are possible.

The bottom line is that at the time you are receiving the benefits of T, your natural T is shut off and you can end up infertile, with smaller testicles (testicular atrophy, in urology parlance)!

Is there an alternative for the symptomatic male with low T?  Can you boost levels of T without shutting down your testes and developing shrunken, poorly functional gonads? 

The answer is an affirmative YES, and one that Big Pharma does not want you to know. There has been such a medication around for 50 years. It has been FDA approved for infertility issues in both sexes and is available on a generic basis. In urology we have used it for many years for men with low sperm counts. Here is a little secret: this medication also raises T levels nicely, and does so by stimulating the testes to secrete natural T rather than shutting them down.  No marble-sized testes that have their function turned to the “off” mode, but respectable family jewels.  The other really good news is that treatment does not necessarily need to be indefinite. The testes can be “kicked” back into normal function, and at some point a trial off the medication is warranted.

The medication is clomiphene citrate, a.k.a Clomid, and I will refer to it as CC. CC is an oral pill commonly used in females to stimulate ovulation and in males to stimulate sperm production. CC is a selective estrogen receptor modulator (SERM) and works by increasing the pituitary hormones that trigger the testes to produce sperm and testosterone. CC blocks E at the pituitary, so the pituitary sees less E and makes more LH and thus more T, whereas giving external T does the opposite, increasing E and thus the pituitary makes less LH and the testes stop making T.

clomiphene-citrate-tablets

Works Like A Charm

CC usually works like a charm in increasing T levels and maintaining sperm production, testes anatomy (size) and function. Its safety and effectiveness profile has been well established and minor side effects occur in proportion to dose and may include (in a small percentage of men): flushes, abdominal discomfort, nausea and vomiting, headache, and rarely visual symptoms.  In general, those with the highest LH levels have the poorest response to CC, probably because they already have maximal stimulation of the testes by the LH.

Not FDA Approved For Low T

One issue is that CC is not FDA approved for low T, only for infertility.  Many physicians are reluctant to use a medication that is not FDA approved for a specific purpose. It needs to be used “off label,” even though it is effective and less expensive than most of the other overpriced T products on the market.

Bottom Line: Treatment to boost T levels should only be done when one has genuine symptoms of low T and a low T level documented on laboratory testing. Using externally-sourced T to boost T successfully raises T and often resolves the symptoms of low T but shuts down the testes and nullifies whatever natural T was being produced as well as sperm production. Clomid is an oral, less expensive alternative that stimulates natural T production and the oral pill formulation is an easier and more discreet delivery system than sloppy gels, injections and pellets.

A study from Journal of Urology (Testosterone Supplementation Versus Clomiphene Citrate: An Age Matched Comparison of Satisfaction and Efficiency. R. Ramasamy, JM Scovell, JR Kovac, LI Lipshultz in J Urol 2014;192:875-9) compared T injections, T gels, CC and no treatment.  T increased from 247 to 504, 224 to 1104 and 230 to 412 ng/dL, respectively, for CC, T injections and gels. Men in all of the 3 treatment arms experienced similar satisfaction. The authors concluded that CC is equally effective as T gels with respect to T level and improvement in T deficiency-related clinical symptoms and because CC is much less expensive than T gels and does not harm testes size or sperm production, physicians should much more often consider CC, particularly in younger men with low T levels.

Wishing you the best of health and a wonderful Memorial Day weekend,

2014-04-23 20:16:29

A new blog is posted weekly. To receive a free subscription with delivery to your email inbox visit the following link and click on “email subscription”:  www.HealthDoc13.WordPress.com

Dr. Andrew Siegel is a physician and urological surgeon who is board-certified in urology as well as in female pelvic medicine and reconstructive surgery.  He is an Assistant Clinical Professor of Surgery at the Rutgers-New Jersey Medical School and is a Castle Connolly Top Doctor New York Metro Area, Inside Jersey Top Doctor and Inside Jersey Top Doctor for Women’s Health. His mission is to “bridge the gap” between the public and the medical community.

Dr. Siegel has authored the following books that are available on Amazon, iBooks, Nook and Kobo:

MALE PELVIC FITNESS: Optimizing Sexual & Urinary Health

THE KEGEL FIX: Recharging Female Pelvic, Sexual and Urinary Health 

PROMISCUOUS EATING: Understanding and Ending Our Self-Destructive Relationship with Food

These books are written for educated and discerning men and women who care about health, well-being, fitness and nutrition and enjoy feeling confident and strong.

Dr. Siegel is co-creator of the male pelvic floor exercise instructional DVD (female version is in the works): PelvicRx

60 Minutes Disses Boston Scientific Meshes: WTF?

May 18, 2018

Andrew Siegel MD  5/18/2018

60 Minutes Trashes Boston Scientific and Pelvic Meshes

Last Sunday, a piece aired on the CBS weekly 60 Minutes concerning Boston Scientific meshes that are used in the field of female urology. The segment was spun in such a way that many viewers were likely to get the wrong impression about Boston Scientific products that are used for two common pelvic floor issues–stress urinary incontinence and pelvic organ prolapse.  These meshes are composed of polypropylene, a synthetic material that is commonly used inside the human body for many purposes, including  hernia repairs as well as a suture material.   I cannot speak for the provenance of the raw materials used for Boston Scientific meshes, although the issue has apparently been addressed by Boston Scientific as well as the FDA, but I can certainly vouch for the safety and effectiveness of their slings and meshes.  After watching the 60 Minutes piece, one might wrongly conclude that Boston Scientific meshes specifically, and all polypropylene meshes generally, are downright dangerous and should never be used in humans.

Au contraire!  Boston Scientific is a reputable company dedicated to both female and male pelvic health and their mesh products (Obtryx mid-urethral sling for stress urinary incontinence and the Uphold Lite for anterior and apical pelvic organ prolapse) are well-designed and clinically effective. I have implanted these products successfully in hundreds of women with stress incontinence and pelvic organ prolapse over the course of many years and will continue to use them.  Furthermore, I have always found the Boston Scientific “reps” to be knowledgeable, available and helpful and the company always willing to provide ample educational opportunities for physicians.  With respect to meshes used for pelvic reconstructive surgery, polypropylene has been the “gold standard” for many years.  Many clinical publications support the safety and effectiveness of polypropylene pelvic floor meshes and numerous medical societies and regulatory bodies have endorsed the utility of polypropylene pelvic meshes for pelvic floor dysfunction.

Proper Repair of a Dropped Bladder (Cystocele)

Not every cystocele is the same, differing in type, extent, symptoms, and degree of bother. The central type (top image below) is a central weakness of the support tissues of the bladder that can cause a pronounced degree of prolapse. The lateral type (bottom image below) is a detachment of the bladder support from the pelvic sidewalls, usually causing only a modest degree of prolapse. Most women have a combination of these two, a combined central-lateral type.

CD

lat defect

 

In my opinion, the classic “plication” repair (sewing together of native tissues)— a.k.a. colporrhaphy—is best suited to a central cystocele in which satisfactory native tissues are present.  However, this will not adequately address a lateral defect cystocele or a combined cystocele. Thus, it is important to determine the type of cystocele in terms of repairing it with native tissues. One of the advantages of a mesh repair is that it addresses all three types of cystocele. Additionally, instead of using native tissue that has already failed in terms of providing adequate structural support, mesh repairs use a strong and durable material to provide support.

Factors influencing me to do a mesh repair over a classic colporrhaphy are the following: poor tissues; risk factors for recurrence including chronic constipation, cough, obesity, and occupations that require manual labor; a relatively young patient who will need a durable repair; and those patients who have already failed a native tissue repair.

In the appropriately selected patient operated on with the proper surgical technique, the results of polypropylene mesh repairs have been extraordinarily gratifying. These procedures pass muster and the “MDSW” test—meaning I would readily encourage my mother, daughter, sister or wife to undergo the procedure if needed. When performed by a skilled pelvic surgeon, the likelihood for cure or vast improvement is great and the likelihood for complications is minimal. Meshes are strong, supple and durable and the procedure itself is relatively simple, minimally-invasive and amenable to outpatient surgery. When patients are seen years after a mesh repair, they are usually extremely satisfied and their pelvic exams typically reveal restored anatomy with remarkable preservation of vaginal length, axis, caliber and depth.

Meshes act as a scaffold for tissue in-growth and ultimately should become fully incorporated by the body. I think of a surgical mesh in a similar way to a backyard chain-link fence that has in-growth of ivy. Meshes examined microscopically years after implantation demonstrate a dense growth of blood vessels and collagen in and around the mesh.

As compared to the classic plication, when a mesh is used for bladder repair, there is rarely any need for trimming the vaginal wall, which makes for a more anatomical repair in terms of vaginal preservation. Another advantage of mesh repairs is that if the patient has a mild-moderate degree of uterine prolapse accompanying the cystocele, the base of the mesh can be anchored to the cervix and thus provide support to the uterus as well as the bladder, potentially avoiding a hysterectomy.

In my opinion, the keys to success are the following: estrogen cream preoperatively in the post-menopausal patient; intravenous and topical antibiotics; a small vaginal incision; good surgical exposure; careful technique making sure the mesh is anchored at the appropriate anatomical sites; trimming the mesh to use the least mesh load possible; avoiding mesh folding, redundancy and tension; and vaginal packing and oral antibiotics post-operatively.

The bottom line is that mesh repairs for pelvic organ prolapse have been revolutionary in terms of the quality and longevity of results—a true game changer. They represent a dramatic evolution in the field of female urology and urological gynecology, offering a vast improvement in comparison to the pre-mesh era. That said, they are not without complications, but the complication rates should be reasonably low under the circumstance of proper patient selection, a skilled and experienced surgeon performing the procedure, excellent surgical technique, utilization of the optimal mesh and patient preparation.

Mesh Integration

Three factors are integral to mesh integration, the process by which the mesh incorporates seamlessly into the body: mesh, patient, and surgeon factors. The goal is for the mesh to fully incorporate into the body so that it can serve its role in providing support to the urethra and/or bladder to cure/improve the stress incontinence and/or cystocele, respectively.

The “gold standard” mesh is large-pored, elastic, monofilament polypropylene. This has been the standard for sling surgery for stress urinary incontinence for over 20 years and for pelvic reconstructions for many years as well. This material is also the standard for mesh hernia repairs and also serves as a hardy suture used for closure of the abdominal wall.

Patient considerations are equally vital.  Risk factors for integration problems include: compromised or poor-quality vaginal tissues; radiated tissues; diabetes; patients on steroids; immune-compromised patients; and patients who use tobacco.

Foremost, a well-trained, experienced pelvic surgeon should be the person doing the mesh implantation. The surgeons most skilled and adept fake newsat this type of surgery are those who have undertaken fellowship training in female pelvic medicine and reconstructive surgery after completion of their urology or gynecology training. It is sensible to check if your surgeon is specialized, and if not, at least has significant clinical experience doing mesh implantation procedures. It is particularly important that the surgeon performing the mesh implant is capable of taking care of any complications that may arise.

The “Mesh-up”

Historically, many of the problems that occurred resulting from mesh implantations were not intrinsic to the mesh itself but were potentially avoidable issues that had to do with surgical technique and/or patient selection. Complications with integration such as mesh exposure—a situation where the mesh is “exposed” in the vagina and is not positioned in the correct surgical plane—can and do occur in a small percentage of patients (even when properly selected and when done by a well-trained pelvic surgeon).  When this situation occurs, it is generally quite manageable, although it will often involve revision surgery if it does not respond to conservative measures.

The crux of the “mesh-up” problem was that a few years ago several of the companies that sold mesh products–in an effort to amplify sales and profits–inappropriately and aggressively promoted their products to physicians who were not trained pelvic surgeons.  They offered “weekend training courses” to general gynecologists, many of whom started implanting pelvic meshes into patients after only a brief training period, often with disastrous results, with many patients sustaining incorporation issues.  This ultimately led to lawsuits and litigation and thereafter several of the mesh companies including Johnson and Johnson Gynecare and American Medical Systems pulled their mesh products off the market.  Fortunately for pelvic surgeons and patients alike, Boston Scientific remained in business, and it is their sling and mesh products that I most commonly implant for female pelvic surgical procedures.

This is not to say that there have not been bad mesh products on the market.  Historically, both the Mentor ObTape and the Tyco IVS sling were poorly designed mesh slings that did not have favorable incorporation features, had horrific results and were ultimately withdrawn from the market.

All of the slings and meshes that remain on the market that are used for pelvic floor surgery in the USA—including the Boston Scientific products–have favorable incorporation features and have been time-tested and have demonstrated their utility. Boston Scientific did not deserve a reaming on 60 Minutes, but I suppose it is irresponsible “spin” that makes for a story and commands advertising dollars.

Wishing you the best of health,

2014-04-23 20:16:29

A new blog is posted weekly. To receive a free subscription with delivery to your email inbox visit the following link and click on “email subscription”:  www.HealthDoc13.WordPress.com

Dr. Andrew Siegel is a physician and urological surgeon who is board-certified in urology as well as in female pelvic medicine and reconstructive surgery.  He is an Assistant Clinical Professor of Surgery at the Rutgers-New Jersey Medical School and is a Castle Connolly Top Doctor New York Metro Area, Inside Jersey Top Doctor and Inside Jersey Top Doctor for Women’s Health. His mission is to “bridge the gap” between the public and the medical community.

Dr. Siegel has authored the following books that are available on Amazon, iBooks, Nook and Kobo:

MALE PELVIC FITNESS: Optimizing Sexual & Urinary Health

THE KEGEL FIX: Recharging Female Pelvic, Sexual and Urinary Health 

PROMISCUOUS EATING: Understanding and Ending Our Self-Destructive Relationship with Food

These books are written for educated and discerning men and women who care about health, well-being, fitness and nutrition and enjoy feeling confident and strong.

Dr. Siegel is co-creator of the male pelvic floor exercise instructional DVD (female version is in the works): PelvicRx

Artificial Urinary Sphincter (AUS): What You Need To Know

May 12, 2018

Andrew Siegel MD   5/12/2018

Severe involuntary leakage of urine following prostate surgery is a rare event, occurring in less than 5% of men following prostatectomy for prostate cancer, and in an even smaller percentage of men who have undergone prostate surgery for a benign process.  Following prostatectomy, it most often results from scarring of the bladder neck sphincter.  Severe incontinence can be devastating to one’s quality of life, affecting psychological, emotional, and sexual well-being and often causing loss of self-esteem, depression, and avoiding a healthy, productive, and active lifestyle.

Fortunately, for the small percentage of men rendered severely incontinent after prostatectomy, the AUS offers a great opportunity for cure and in significantly improving quality of life. It functions as a mechanical compression device of the urethra that is under the patient’s control, providing simple and discreet control over bladder storage and emptying.  Implanted entirely within the body, the device mimics the function of a healthy sphincter muscle by keeping the urethra closed until the patient desires to urinate.

The AUS prosthesis is a saline fluid-filled device composed of solid silicone elastomer consisting of three interconnected components: a cuff implanted around the urethra, a pressure-regulating balloon reservoir implanted behind the pubic bone, adjacent to the bladder, and a control pump implanted in the scrotum.  The cuff gently squeezes the urethra closed, preventing urine from passing.  When one wants to urinate, he simply squeezes and releases the control pump that is situated in the scrotum, temporarily transferring fluid from the cuff to the pressure regulating balloon.  The cuff opens, allowing urine to flow through the urethra.  Within several minutes, the pressure regulating balloon automatically returns the fluid to the cuff to once again pinch the urethra closed.

Blausen_0059_ArtificialUrinarySphincter

The AUS, first developed in 1972, has been used successfully for over 45 years and has been implanted in more than 150,000 men. Over the years, biomedical engineering refinements have further improved the AUS.  About two thirds of men will be completely continent after an AUS implant, and the other one third will experience only minor incontinence, requiring one or two small pads per day. The overall patient satisfaction rate exceeds 90%.

In order to be an appropriate candidate for the AUS, incontinence needs to be on the basis of a weakened or damaged sphincter and not due to bladder over-activity.  Additionally,  bladder capacity needs to be adequate and urinary flow rate sufficient to empty the bladder. The incontinence should be present for a minimum of 6 months before considering the AUS, since spontaneous improvement occurs for some time after prostatectomy. One obviously need to be sufficiently motivated to receive an implant, and its use demands manual dexterity in order to operate the control pump.

Implantation of the Artificial Urinary Sphincter

Implantation of the AUS is a one hour or so outpatient surgical procedure done under anesthesia.  The conventional operation is performed with one’s legs in stirrups and requires one incision in the abdomen and the other in the perineum (area between scrotum and anus).  In 2003, Dr. Steve Wilson and I devised an innovative technique for AUS implantation via a single scrotal incision. The advantages of the scrotal technique are a single incision, the fact that it can be done supine (lying on one’s back versus legs up in stirrups), faster operative time, ease of doing the procedure and decreased patient discomfort.  In either case, the control pump is one-size fits all, but the cuff is precisely measured to your anatomy and the pressure-regulating balloon reservoir is usually chosen to be 61-70 cm water pressure.

It is important to know that the AUS will not be activated– and thus will not be functional– for about a 6-week period of time to allow for healing of tissues. Activation is a simple process that is done in the office, involving minimal discomfort.

It is advisable to order and wear a MedicAlert bracelet (www.medicalert.org) to inform health care personnel that you have an AUS implant in the event of a medical emergency. If you were rendered unconscious or unable to communicate, this bracelet will inform emergency medical staff that you have an AUS, because if there is ever a need for a urethral catheter, it is imperative that the AUS be deactivated prior to catheter placement in order to avoid damaging the urethra.

FAQ

Who manufactures the AUS?

American Medical Systems Men’s Health Division of Boston Scientific, Inc. http://www.BostonScientific.com

Will insurance cover the AUS?

Medicare has a coverage policy for incontinence control devices, which includes the AUS.  Most commercial health insurers also cover the AUS when deemed medically necessary for the patient.

How effective is the AUS?

More than 90% of patients with the AUS have greatly improved continence, many of whom achieve complete urinary control with no need for pads and the remainder of whom have occasional, minor stress incontinence with vigorous activities, typically requiring one or two small pads per day.  The 61-70 cm pressure regulating balloon provides 61-70 cm of pressure around the urethra, which is sufficient closure for most of the activities of daily living.

Does the AUS need to be measured to my body?

The control pump is “one size fits all”, but the cuff is sized to the circumference of your urethra to achieve a proper fit.  The reservoir comes in a variety of pressures.  The higher the pressure of the reservoir, the tighter the closure of the urethra. The tighter the closure of the urethra, the better is the continence, but also the greater the chance of urethral damage from the higher pressures. A balance must be achieved in order to achieve the necessary pressure to achieve continence while minimizing potential damage to the urethra. In practical terms, this translates into a 61-70 cm. pressure reservoir for most men.

Can I have an AUS if I underwent surgery followed by radiation therapy?

Yes, but radiation therapy increases the  potential risk for complications because of tissue damage, scarring, decreased blood flow and less optimal wound healing.

What are alternatives to the AUS, assuming that behavioral techniques and pelvic floor muscle exercises have failed?

  1. Absorbent pads and garments
  2. Penile compression clamps
  3. External collecting devices
  4. Urethral bulking agents
  5. The male sling

The first three are external, bulky, mechanical means of coping with–not treating–the problem.  Urethral bulking agents have fared poorly and the male sling is a possibility, although it is indicated for lesser degrees of incontinence and achieves results far inferior to those possible with the AUS.

Who should not have an AUS prosthesis?

The AUS is not appropriate for a man with an obstructed lower urinary tract. It also should not be used for those with bladder-related incontinence (overactive bladder or a small-capacity, scarred bladder) as it is indicated only for those with sphincter-related incontinence. It cannot be effectively used in those with compromised dexterity or mental acuity.

What are the potential risks and complications associated with AUS implantation?

Infection   As with any surgery, an infection can develop after an AUS implant.  Every step is taken to reduce the likelihood of an infection, including intravenous antibiotics, an antiseptic scrub of the surgical site on the operating table followed by the application of an chlorhexidine and alcohol skin antiseptic immediately prior to the operation, double-gloving, meticulous surgical technique with the procedure done as quickly as possible, topical antibiotics to flush the surgical site, and minimizing operating room traffic. Antibiotic ointment is placed on the surgical incision prior to placing the surgical dressing. Patients are sent home with oral antibiotics.

Two of the three components of the AUS–the cuff and pump–are coated with an antibiotic combination called InhibiZone, which consists of rifampin and minocycline.  If an infection occurs and does not respond to antibiotics, it may be necessary to remove the AUS, an extremely rare occurrence.

MH AMS 800 urinary sphincter product

Image above: AUS with inhibiZone coating of control pump and cuff

 

Erosion   This is a breakdown of the urethral tissues that lie beneath the cuff.   It is generally treated with cuff removal to allow for urethral healing prior to consideration for cuff replacement at a later date.  Erosion can occur when a catheter is placed into the urinary bladder by health care personnel uninformed that the AUS device is in place. The delicate urethra, pinched closed by the inflated cuff surrounding it, is traumatized and damaged by catheter placement.  This situation can be avoided by deactivating the AUS prior to catheterization.  This is one of the reasons that a MedicAlert card and bracelet are useful considerations. Erosion of the other AUS components can also occur on a rare basis. The control pump can potentially erode through the scrotal skin and the pressure-regulating balloon reservoir into the urinary bladder.

Mechanical Malfunction   The AUS is effective and reliable, but it is a mechanical device that can ultimately malfunction. It is not possible to predict how long an AUS will function in an individual patient.  As with any biomedical prosthesis, this device is subject to wear, component disconnection, component leakage, and other mechanical problems that may lead to the device not functioning as intended and may ultimately require additional surgery to replace the device. The median durability of the device is about 7.5 years, although I have patients who still have a functional AUS 20 years after implantation.

Urethral Tissue Atrophy   This can result from the long-term pressure effect of the cuff on the urethra.  Essentially, the urethra shrinks down from being squeezed by the cuff, resulting in worsening of urinary control.  When this happens, it generally requires repositioning of the cuff to a new urethral location or the use of a smaller cuff or, on rare occasion, placement of a second cuff (tandem cuff).

Pain    Discomfort in the groin, penis, and scrotum is expected immediately after surgery and during the period when the device is first used. It is very rare to experience chronic pain from an implantation of an AUS.

Migration and Extrusion  Migration is the movement or displacement of components within the body space in which they were originally implanted.  Extrusion occurs when a component moves to an abnormal location outside of the body.  These are both extremely rare occurrences

Bottom Line: The artificial urinary sphincter (AUS) is an effective, safe and reliable implantable medical prosthesis to restore urinary control in men with severe, refractory stress urinary incontinence.  Although there is no means of totally replacing our natural sphincter system, the AUS is the only device that simulates normal sphincter function by opening and closing the urethra at the will of the patient. It provides consistent results in the treatment of incontinence following prostatectomy and is considered to be the “gold standard” in the management of this problem. Many patients report that the AUS is nothing short of “life changing,” converting men who are bladder “cripples” back to normal function and restoring their quality of life. 

Wishing you the best of health,

2014-04-23 20:16:29

A new blog is posted weekly. To receive a free subscription with delivery to your email inbox visit the following link and click on “email subscription”:  www.HealthDoc13.WordPress.com

Dr. Andrew Siegel is a physician and urological surgeon who is board-certified in urology as well as in female pelvic medicine and reconstructive surgery.  He is an Assistant Clinical Professor of Surgery at the Rutgers-New Jersey Medical School and is a Castle Connolly Top Doctor New York Metro Area, Inside Jersey Top Doctor and Inside Jersey Top Doctor for Women’s Health. His mission is to “bridge the gap” between the public and the medical community.

Dr. Siegel has authored the following books that are available on Amazon, iBooks, Nook and Kobo:

MALE PELVIC FITNESS: Optimizing Sexual & Urinary Health

THE KEGEL FIX: Recharging Female Pelvic, Sexual and Urinary Health 

PROMISCUOUS EATING: Understanding and Ending Our Self-Destructive Relationship with Food

These books are written for educated and discerning men and women who care about health, well-being, fitness and nutrition and enjoy feeling confident and strong.

Dr. Siegel is co-creator of the male pelvic floor exercise instructional DVD (female version is in the works): PelvicRx

Urethral Lozenge To Treat E.D.: What You Need to Know

May 5, 2018

Andrew Siegel MD   5/5/18

In Greek and Roman mythology, the muses were the goddess daughters of Zeus and Mnemosyne who presided over the arts and sciences. The term is now used to refer to a source of inspiration for a creative artist.  Today’s entry discusses a different kind of muse, technically M.U.S.E., an acronym for “medical urethra system/suppository for erection.” For men suffering with E.D., M.U.S.E. can be a source of inspiration for better quality erections.

In a practical approach to ED, vasodilating drugs (those that expand blood vessels and increase blood flow) can be considered to be third-line treatments for ED. MUSE is formulated as a urethral lozenge (suppository) that when absorbed functions to increase penile blood flow and induce an erection.

MUSE (Medical urethral system for erection) consists of alprostadil (prostaglandin E1) vasodilator pellets—available in 125, 250, 500, and 1000 microgram dosages—that are placed into the urinary channel after urinating.  Absorption occurs through the urethra into the adjacent erectile chambers, inducing increased penile blood flow and potentially an erection.

IMG_8823

Image above is the MUSE applicator with the MUSE pellet contained within

One of the problems with MUSE is that it is placed in the urethra, which has little to no role in erectile function, although it is surrounded by one of the erectile chambers (corpus spongiosum) that gets plump, although not rigid at the time of an erection. The neighboring paired erectile chambers (corpora cavernosa) are the two bodies that become rigid at the time of an erection. MUSE relies on the medication being locally absorbed from the urethra, into the corpus spongiosum and then into the corpora cavernosa.

Why did Willie Sutton rob banks?  Because that’s where the money is.  When it comes to erections, the money is in the corpora cavernosa.  Using MUSE is like robbing the building next to the bank.  Because it relies on absorption to an adjacent structure, the dosage required is significantly higher than when the medication is injected directly into the corpus cavernosum (penile injection therapy).  You may need to use a 1000 microgram pellet in the urethra, whereas if injected you might only need 10 micrograms. MUSE is effective in about 30-40% of men, working in about 15 minutes or so and resulting in an erection lasting for about an hour.

How to use MUSE:

Note: An applicator delivers the medicated pellet into the tip of the penis. It should be inserted after urinating, which functions to lubricate the urethra and make the administration easier.  The pellet is formulated to dissolve in the small amount of urine remaining in the urethra after urination.

  1. After the applicator is removed from the foil pouch, remove the protective cover from the applicator stem. The medicated pellet is visible because the applicator is transparent.
  2. Put the penis on full stretch and gently compress the head of the penis to straighten and open the urethra.
  3. Gently insert the applicator in the urethra to the level of the collar of the applicator.
  4. Push down on the button on the top of the applicator and hold for a few seconds to deploy the pellet.
  5. Gently rock the applicator from side to side to separate the pellet from the applicator tip and then remove the applicator and inspect to ensure release of the pellet.
  6. Holding the penis upright and stretched, kneed the penis between your hands for at least 10 seconds; if you feel a burning sensation, continue to kneed the penis until it subsides.
  7. Replace the cover on the applicator, place it in the opened foil pouch and discard.
  8. Stand up or walk around for 10 minutes or so while the erection is developing. Voila!

Side effects include urethral burning, aching in the penis, testicles, perineum and legs, redness of the penis and minor urethral bleeding or spotting.

Bottom Line: MUSE is another tool in the urologist’s erectile dysfunction toolbox.  Although it is not highly effective and its means of administration (via a urethral lozenge) may be distasteful to many, nonetheless it can be a means of improving ED for men who do not respond to lifestyle measures and the oral ED medications. 

Wishing you the best of health,

2014-04-23 20:16:29

A new blog is posted weekly. To receive a free subscription with delivery to your email inbox visit the following link and click on “email subscription”:  www.HealthDoc13.WordPress.com

Dr. Andrew Siegel is a physician and urological surgeon who is board-certified in urology as well as in female pelvic medicine and reconstructive surgery.  He is an Assistant Clinical Professor of Surgery at the Rutgers-New Jersey Medical School and is a Castle Connolly Top Doctor New York Metro Area, Inside Jersey Top Doctor and Inside Jersey Top Doctor for Women’s Health. His mission is to “bridge the gap” between the public and the medical community.

Dr. Siegel has authored the following books that are available on Amazon, iBooks, Nook and Kobo:

MALE PELVIC FITNESS: Optimizing Sexual & Urinary Health

THE KEGEL FIX: Recharging Female Pelvic, Sexual and Urinary Health 

PROMISCUOUS EATING: Understanding and Ending Our Self-Destructive Relationship with Food

Cover

These books are written for educated and discerning men and women who care about health, well-being, fitness and nutrition and enjoy feeling confident and strong.

Dr. Siegel is co-creator of the male pelvic floor exercise instructional DVD (female version is in the works): PelvicRx

 

What’s Your E.Q. (Erection Quotient)?

April 28, 2018

Andrew Siegel, M.D.  4/28/18

shutterstock_side view manjpeg

The S.H.I.M. test is the “Sexual Health Inventory for Men.”  It is a simple 5 question test that urologists use to subjectively test for the presence and extent of erectile dysfunction (ED).  It is commonly used metric for screening, diagnosing and determining the severity of ED in clinical practice and research.  It is very useful before prostate cancer surgery to obtain a baseline appraisal of the presence, rigidity, durability and functionality of one’s erection.

 

Go ahead and test your own erection quotient.  For each question, note your answer by circling the number that best describes your function.
 Add the numbers together and refer to the table below to see what your score may mean.

Over the past 6 months:

How do you rate your confidence that you could get and keep an erection?

  1. Very low
  2. Low
  3. Moderate
  4. High
  5. Very high

When you had erections with sexual stimulation, how often were your erections hard enough for penetration?

  1. Almost never/never
  2. A few times (less than half)
  3. Sometimes (about half)
  4. Most times (much more than half)
  5. Almost always

During sexual intercourse, how often were you able to maintain your erection after you had penetrated (entered) your partner?

  1. Almost never/never
  2. A few times (less than half)
  3. Sometimes (about half)
  4. Most times (much more than half)
  5. Almost always

During sexual intercourse, how difficult was it to maintain your erection to completion of intercourse?

  1. Almost never/never
  2. A few times (less than half)
  3. Sometimes (about half)
  4. Most times (much more than half)
  5. Almost always

 When you attempted sexual intercourse, how often was it satisfactory for you?

  1. Almost never/never
  2. A few times (less than half)
  3. Sometimes (about half)
  4. Most times (much more than half)
  5. Almost always

 

SHIM scoring:

The SHIM score is the numerical sum of the responses to the 5 items.

22-25: No erectile dysfunction

17-21: Mild erectile dysfunction

12-16: Mild to moderate erectile dysfunction

8-11: Moderate erectile dysfunction

5-7: Severe erectile dysfunction

2-Piece Penile Prosthesis for Erectile Dysfunction

April 21, 2018

Andrew Siegel MD  4/21/2018

Penile prostheses are surgically implanted devices that create on-demand penile rigidity to enable sexual intercourse. There are two major types: semi-rigid and inflatable.  Today’s entry explores a third option, a 2-piece unit that can be considered a hybrid between the simple 1-piece semi-rigid device and the more complex 3-piece inflatable device.  (All images are courtesy of AMS Men’s Health Boston Scientific).

The semi-rigid penile prosthesis is a 1-piece device that always remains rigid and is bent upwards for sex and bent downwards for concealment purposes. It consists of two malleable rods that are implanted within the erectile chambers through a small incision.

Advantage: simple, effective, no dexterity required, no need for control pump or reservoir, “ever-ready” for sex.   Disadvantage: always rigid, concealment can be tricky, 24-7 erection can make the tip of the penis sore.                                                                              

The inflatable penile prosthesis (IPP) is 3-piece device designed to mimic a normal erection, with the capacity to inflate and deflate via a self-contained hydraulic system. The inflatable cylinders are implanted within the penile erectile chambers. A control pump is implanted in the scrotum for easy access and the fluid-containing reservoir is implanted behind the pubic bone or behind the abdominal muscles. Erections are obtained by pumping the control pump several times, which transfers fluid from the reservoir to the cylinders and voila, a rigid erection is obtained that will remain so until the deflate mechanism on the control pump is used to transfer the fluid back from the cylinders to the reservoir.

Advantage: closes mimics normal erection, highly effective, concealment not issue Disadvantage: more complex and although well-engineered, has higher malfunction rate than semi-rigid alternative, requires dexterity.

Ah, but there is a third option that is somewhat of a hybrid between the 1-piece malleable rods and the 3-piece inflatable device. It is an inflatable 2-piece unit that offers the benefits of the 3-piece device with the simplicity of the 1-piece device. By eliminating the reservoir as a separate component, it provides advantages to both the patient as well as the implanting urologist. It is called the Ambicor and is a product of the American Medical Systems Men’s Health division of Boston Scientific.

AMS Ambicor product imageThe Ambicor device (see image above)  incorporates the reservoir into the inner part of the inflatable cylinders as opposed to a separate reservoir with the 3-piece device. The Ambicor cylinders are composed of inner and outer silicone tubes with a woven fabric in between.  The Ambicor is a pre-filled hydraulic device comes in 3 different widths and in an assortment of lengths, so that any man can be appropriately sized.

Operating the Ambicor: Inflation is achieved by compressing the pump implanted into the scrotum, which transfers fluid from the built-in reservoirs in the proximal cylinders (seated in the deep, inner penis) to the distal part of the cylinders (seated in the external, outer part of the penis). The device is deflated by simply bending the cylinders for 10 seconds or so, which triggers a release valve that returns the fluid from the distal cylinders to the proximal cylinders.

2

 

 

3

The Ambicor is particularly advantageous in certain circumstances: patients who have had extensive abdominal/pelvic surgery in whom implanting an abdominal reservoir might present challenges and complications; those with poor manual dexterity, since it is easier to inflate and deflate than the 3-piece alternative; and patients with kidney transplants or anticipated transplants in the future (kidney transplants are positioned in  the pelvis, close by to where the reservoirs of penile prostheses are placed).  The Ambicor is not ideal in patients with Peyronie’s disease or scarred, short penises (less natural appearance when deflated because the firm tip of device does not deflate) or long and narrow penises (in this situation there is less support on the axis of the penis that can cause buckling and trigger deflation).

Advantage: mimics normal erection, effective, limited dexterity required, no abdominal reservoir required.  Disadvantage: spontaneous deflation (from triggering deflation mechanism during sex), spontaneous inflation when there is scarring of erectile chambers, not ideal in those with short penises or long and narrow penises.

Bottom line: When simpler measures fail to cure ED, penile prostheses are an excellent option. The surgical implantation is an outpatient procedure done under anesthesia that requires only a small incision.  The different prostheses vary in design and complexity (1, 2 and 3-components), but all aim to give the user a reliable erection on demand. The Ambicor, manufactured by American Medical Systems Men’s Health division of Boston Scientific, can be considered a hybrid between the simple but limited functionality of the 1-piece semi-rigid device and the complex and greater functionality of the 3-piece inflatable device. In appropriately selected patients the Ambicor has proven to be reliable and user-friendly with high rates of patient and partner satisfaction.  

Wishing you the best of health,

2014-04-23 20:16:29

A new blog is posted weekly. To receive a free subscription with delivery to your email inbox visit the following link and click on “email subscription”:  www.HealthDoc13.WordPress.com

Dr. Andrew Siegel is a physician and urological surgeon who is board-certified in urology as well as in female pelvic medicine and reconstructive surgery.  He is an Assistant Clinical Professor of Surgery at the Rutgers-New Jersey Medical School and is a Castle Connolly Top Doctor New York Metro Area, Inside Jersey Top Doctor and Inside Jersey Top Doctor for Women’s Health. His mission is to “bridge the gap” between the public and the medical community.

Dr. Siegel has authored the following books that are available on Amazon, iBooks, Nook and Kobo:

MALE PELVIC FITNESS: Optimizing Sexual & Urinary Health

THE KEGEL FIX: Recharging Female Pelvic, Sexual and Urinary Health 

PROMISCUOUS EATING: Understanding and Ending Our Self-Destructive Relationship with Food

Cover

These books are written for educated and discerning men and women who care about health, well-being, fitness and nutrition and enjoy feeling confident and strong.

Dr. Siegel is co-creator of the male pelvic floor exercise instructional DVD PelvicRx

 

“Butterflies” In Your Penis: What You Need To Know About Performance Anxiety/E.D.

April 14, 2018

Andrew Siegel MD   4/14/18

“It is like a firstborn son—you spend your life working for him, sacrificing everything for him, and at the moment of truth he does just as he pleases.”

Gabriel Garcia Marquez, Love In the Time of Cholera

“The penis does not obey the order of its master, who tries to erect or shrink it at will. Instead, the penis erects freely while its master is asleep. The penis must be said to have its own mind, by any stretch of the imagination.”

Leonardo da Vinci

 

brain-303186_1280.png

The brain is the biggest and most important sex organ, the “conductor of the orchestra

( Thank you, Pixabay, for image above)

 

Every man at one time or another may experience a situational erection problem due to  circumstances. As intoxicating and exciting as a new relationship can be, situational erection problems are not uncommonly experienced because of the anxiety and concerns that can surface when encountering a new sexual partner.  Additional contributing factors can be other life stresses, fatigue, too much alcohol consumption, recreational drugs, etc.

Men are human beings and not robots that can always function on command. It is not always easy to “stand and deliver” and, unquestionably, the lion’s share of the sexual “burden” is on the male.  In the circumstance of failure to achieve a good quality erection in a new sexual situation, it is not a matter of insufficient male rocket fuel (testosterone), poor sexual desire,  malfunctioning plumbing or sexual orientation.  It’s all about chemistry and by this I do not mean the attraction and spark kind of chemistry between two individuals.

The brain is the most important sex organ and the mind-body connection is profound. One’s emotional state drives the release of a “cocktail” of chemicals that can make or break their ability to perform any pursuit, whether it is giving a speech, sports or in the bedroom. When it comes to the bedroom, one’s internal “biochemical environment” at any given moment in time can chemically promote a bone-hard erection or, at times, no erection at all.  The problem is not with the hardware, but with the software!

Performance anxiety is nothing other than stage fright—the stage the bedroom—due to emotional stress (whether conscious or subconscious) that causes the release of adrenaline, the “flight or fright” chemical that causes tightening of blood vessels and restriction of blood flow to the penis.

Adrenaline is an amazing chemical to have onboard when you are in precarious situation, such as being chased by a lion in the jungle. It causes your pupils to dilate, blood pressure to rise and pulse and breath to quicken.  This stress hormone that is churned out by the adrenal glands prepares you to confront the danger in a turbo-charged state so that you can react optimally.  However, adrenaline causes a restriction of blood flow to non-vital organs including the penis, so that blood flow can be directed to where it best serves one to deal with the precarious situation. The point is that stress does not belong in the same sentence as sex, and when it does, it is a formula for a losing situation. For some men, the stress of having to wear a condom can doom the erection to failure.

Fact: On the occasion that a man has a prolonged erection (a.k.a. priapism) that lasts for more than four hours, an adrenaline-like drug is injected directly into the erectile chambers of the penis to cause the erection to subside. 

The chemistry of erections and performance anxiety

The chemistry of erections: With erotic stimulation or touch, the erectile nerves release nitric oxide, which in turn causes the release of cGMP. This causes the erectile chamber arteries to expand and blood to gush into the penis and also causes the smooth muscle of the erectile chambers to relax, allowing space for blood to fill the erectile chambers.  The chemistry of defeat: If enough adrenaline is present, the erectile arteries will narrow and the smooth muscle of the erectile chambers will contract. The presence of enough adrenaline trumps the presence of nitric oxide and cGMP.

The psychology of performance anxiety

What goes on in the man’s mind: Performance anxiety often “gets in the head” of the man plagued with it.   Excessively focusing and dwelling on the issue further decreases the likelihood of obtaining a rigid erection by creating a self-fulfilling prophecy of failure. When entering a sexual situation preoccupied with anxiety and doubts, one often ends up being a spectator of his own performance (Masters and Johnson referred to this as “spectatorating”), instead of being in the moment and present as one needs to be to be able to function properly, often dooming one’s erectile potential.

What goes on in the female’s mind: As they say, “It takes two to tango.”  Another big problem is the partner’s interpretation of the man’s inability to obtain and/or maintain an erection. The partner, confronted with the poorly functioning male, commonly thinks—erroneously– that the root of the problem is that the man does not sufficiently care for her,  find her attractive or that her sexual allure and proficiency is lacking.

So, the male not only has performance anxiety, but often experiences secondary anxiety from being consumed by the problem, creating a “vicious cycle.”  And the female now has anxiety and concerns about her looks, her skills in the bedroom, his feelings, the future of the relationship, etc.  This is clearly not a good combination for the start of a healthy relationship!  The truth of the matter is that the root of the problem is neither the man’s plumbing, his sexual orientation, nor his feelings about his partner and it is not a question of the female’s attractiveness, allure or sexual prowess.

Bottom Line: Performance anxiety is a common form of emotional stress that can be experienced with a new sexual partner.  Enter adrenaline in high enough levels and an erection will never occur, or if it does so, will rapidly be lost. Adrenaline may be your friend in life and death situations, but not in the bedroom!  Although oral ED medications (Viagra, Cialis, etc.) can chemically kick-start and often help counter performance anxiety and break the vicious cycle that has been established, adrenaline is such a powerhouse chemical that it can sometimes even doom an erection in a man who has taken performance-enhancing drugs.

The female in the relationship should understand that she is not the cause of the problem and she should not hold herself nor her partner accountable, which serves to further exacerbate the stress and anxiety.  Rather, she should stay calm, be understanding and supportive and realize that once her partner becomes more comfortable with the relationship, the anxiety and the problem will most often magically disappear.

Finally, it is important to understand that other common sexual issues, including premature ejaculation and delayed ejaculation, elicit virtually the identical psychological and emotional responses from both male and female partners as does performance anxiety.

Wishing you the best of health,

2014-04-23 20:16:29

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Dr. Andrew Siegel is a physician and urological surgeon who is board-certified in urology as well as in female pelvic medicine and reconstructive surgery.  He is an Assistant Clinical Professor of Surgery at the Rutgers-New Jersey Medical School and is a Castle Connolly Top Doctor New York Metro Area, Inside Jersey Top Doctor and Inside Jersey Top Doctor for Women’s Health. His mission is to “bridge the gap” between the public and the medical community.

Dr. Siegel has authored the following books that are available on Amazon, iBooks, Nook and Kobo:

MALE PELVIC FITNESS: Optimizing Sexual & Urinary Health

THE KEGEL FIX: Recharging Female Pelvic, Sexual and Urinary Health 

PROMISCUOUS EATING: Understanding and Ending Our Self-Destructive Relationship with Food

Cover

These books are written for educated and discerning men and women who care about health, well-being, fitness and nutrition and enjoy feeling confident and strong.

Dr. Siegel is co-creator of the male pelvic floor exercise instructional DVD (female version is in the works): PelvicRx